Study of tamoxifen urinary metabolites in rat by ultra-high-performance liquid chromatography time-of-flight mass spectrometry

Author:

Domínguez-Romero Juan C.1,García-Reyes Juan F.1,Beneito-Cambra Miriam1,Martínez-Romero Rubén2,Martinez-Lara Esther2,Del Moral-Leal María L.2,Molina-Díaz Antonio1

Affiliation:

1. Analytical Chemistry Research Group, Department of Physical and Analytical Chemistry; University of Jaén; 23071 Jaén Spain

2. Cellular Stress and Age Research Group. Department of Experimental Biology; University of Jaén; 23071 Jaén Spain

Funder

Junta de Andalucía

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference37 articles.

1. Hydroxylated metabolites of tamoxifen are formed in vivo and bound to estrogen receptor in target tissues;Borgna;Journal of Biological Chemistry,1981

2. Tamoxifen and metabolites in MCF7 cells: Correlation between binding to estrogen receptor and inhibition of cell growth;Coezy;Cancer Research,1982

3. An ultra performance liquid chromatography-tandem MS assay for tamoxifen metabolites profiling in plasma: first evidence of 4′-hydroxylated metabolites in breast cancer patients;Dahmane;Journal of Chromatography B,2010

4. Quantitative monitoring of tamoxifen in human plasma extended to 40 metabolites using liquid chromatography high-resolution mass spectrometry: new investigation capabilities for clinical pharmacology;Dahmane;Analytical and Bioanalytical Chemistry,2014

5. Serum and urine levels of tamoxifen in patients with advanced breast cancer after a loading dose at steady-state levels;De Vos;Cancer Chemotheraphy and Pharmacology,1998

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