Development and validation of a UHPLC-UV method for the determination of a prostate secretory protein 94-derived synthetic peptide (PCK3145) in human plasma and assessment of its stability in human plasma

Author:

El Mubarak Mohamed A.1,Leontari Iliana1,Danika Charikleia1,Katsila Theodora1,Sivolapenko Gregory1

Affiliation:

1. Department of Pharmacy, Laboratory of Pharmacokinetics; University of Patras; Patras Greece

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference13 articles.

1. European Medicines Agency Guideline on Bioanalytical Method Validation July 2011 http://www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2011/08/WC500109686.pdf

2. Levels of beta-microseminoprotein in blood and risk of prostate cancer in multiple populations;Haiman;Journal of the National Cancer Institute,2013

3. Safety and tolerability of PCK3145, a synthetic peptide derived from prostate secretory protein 94 (PSP94) in metastatic hormone-refractory prostate cancer;Hawkins;Clinical Prostate Cancer,2005

4. Three predominant proteins secreted by the human prostate gland;Lilja;Prostate,1988

5. Decreased expression of prostatic secretory protein PSP94 in prostate cancer;Liu;Cancer Letters,1993

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