Effects of treatment with Glucagon‐like peptide‐1 receptor agonist on prediabetes with overweight/obesity: A systematic review and meta‐analysis

Author:

Wang Weihao1ORCID,Wei Ran12,Huang Zhengxiang3,Luo Jingyi1,Pan Qi1,Guo Lixin12

Affiliation:

1. Department of Endocrinology Beijing Hospital National Center of Gerontology Institute of Geriatric Medicine Chinese Academy of Medical Sciences Beijing China

2. Peking University Fifth School of Clinical Medicine Beijing China

3. School of Biomedical Sciences University of Queensland St Lucia Brisbane Australia

Abstract

AbstractObjectiveThis study aimed to evaluate the effects of Glucagon‐like peptide‐1 receptor agonist (GLP‐1RA) on prediabetes with overweight/obesity.MethodsA search of PubMed, Embase, Cochrane Library, and Web of Science databases was performed to identify randomised controlled trials (up to 4 July 2022) which evaluated the effect of GLP‐1RA on prediabetes with overweight/obesity.ResultsEight hundred and nine articles were retrieved (80 from PubMed, 481 from Embase, 137 from Cochrane library, and 111 from Web of Science) and a total of 5 articles were included in this meta‐analysis. More individuals in GLP‐1RAs group regressed from prediabetes to normoglycemia than individuals in the placebo group (OR = 4.56, 95% CI:3.58, 5.80, P = 0.004); fewer individuals in GLP‐1RAs group were diagnosed with diabetes than those in the placebo group (OR = 0.31, 95% CI:0.12,0.81, P = 0.017). Results from five studies showed that GLP‐1RAs significantly reduced fasting glucose (mean difference = −0.41 mmol/L, 95% CI: −0.58, −0.25, P < 0.00001), with an acceptable heterogeneity (I2 = 42%).ConclusionsThe present meta‐analysis suggested that GLP‐1RA significantly improves glucose metabolism, reduces systolic blood pressure and body weight in prediabetes with overweight/obesity. It could also prevent the development of diabetes and reverse abnormal glucose metabolism.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Endocrinology,Endocrinology, Diabetes and Metabolism,Internal Medicine

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