Affiliation:
1. Institute of Chemistry Saint Petersburg State University 26 Universitetskii prospect, Peterhof Saint Petersburg 198504 Russia
Abstract
AbstractSynthetic methodologies based on cycle expansion reactions have proven to be highly effective in delivering valuable medium‐sized cycles and macrocycles. A primary method of ring expansion relies on intramolecular transamidation reactions. These reactions typically employ N‐aminoalkyl and N‐aminoacyl derivatives of lactams and their analogues as starting materials, yielding a diverse spectrum of unique nitrogen‐containing heterocycles.This Review aims to provide a comprehensive analysis of the research outcomes related to intramolecular transamidation reactions that lead to cycle expansion. This will offer the reader a perspective on the potential applications of such reactions in generating novel and intriguing types of heterocyclic systems.
Funder
Russian Science Foundation
Subject
Organic Chemistry,Physical and Theoretical Chemistry