Preparation of α‐Deuterated Lactic Acid Derivatives through Remote Heteroaryl Migration and Radical‐Polar Crossover Deuteration

Abstract

AbstractA novel photoredox‐neutral 1,2,5‐trifunctionalization of α‐hydroxyhexenoates is disclosed. The radical cascade proceeds via heteroaryl migration‐enabled alkene fluoroalkylheteroarylation and radical‐polar crossover deuteration, leading to functionalized α‐deuterated lactic acid derivatives. The reaction features mild photochemical conditions and provides an efficient approach for the synthesis of valuable deuterated molecules.