Affiliation:
1. Institute of Industrial Science The University of Tokyo 4-6-1 Komaba Meguro-ku Tokyo 153–8505 Japan
Abstract
AbstractKinetic resolution of 4‐(2‐nitrovinyl)[2.2]paracyclophane based on N‐terminal–guanidinylated resin–bound helical peptide catalyzed asymmetric Michael addition of malonate esters was developed. This approach provides a new pathway to enantiopure paracyclophane derivatives characterized by both planar and central chirality, along with the recovery of the chiral substrate with a selectivity factor of up to 111. Additionally, the synthetic potential of the resulting products has been showcased through their successful transformation into derivatives of β‐substituted γ‐aminobutyric acid.
Funder
Japan Society for the Promotion of Science
Ministry of Education, Culture, Sports, Science and Technology
Cited by
1 articles.
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