Affiliation:
1. Asymmetric Synthesis and Chiraltechnology Key Laboratory of Sichuan Province Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu China
2. University of Chinese Academy of Sciences Beijing China
3. Department of Chemistry Xihua University Beijing China
Abstract
AbstractIsoxazolopyridines are highly significant for the development of pharmaceuticals and new materials. In continuation of our ongoing research on transformations of 5‐aminoisoxazoles, we report herein a divergent synthesis of two kinds of novel isoxazolo[5,4‐b] pyridines through condensation of 5‐aminoisoxazoles with β,γ‐alkynyl‐α‐imino esters. By using two different silver salts and a phosphoric acid as catalysts, isoxazolo[5,4‐b] pyridine‐α‐carboxylates and isoxazolo[5,4‐b] pyridine‐γ‐carboxylates were constructed as major isomers in moderate to good yields, respectively. The structures of the two kinds of the isoxazolo[5,4‐b] pyridines were confirmed by X‐ray crystal structural analysis. Furthermore, control experiments were conducted to elucidate the reaction mechanism.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献