I2‑DMSO‐Mediated Cascade Cyclization of β‐Ketosulfoxonium Ylides and β‐Enaminones: Synthesis of Quaternary Carbon Centered 2‐Hydroxy‐pyrrol‐3(2H)‐ones
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Published:2023-07-19
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Volume:
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ISSN:1434-193X
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Container-title:European Journal of Organic Chemistry
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language:en
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Short-container-title:Eur J Org Chem
Author:
Saini Rahul Kumar1,
Borpatra Paran J.1,
Pandey Satyendra Kumar2
Affiliation:
1. Banaras Hindu University Department of Chemistry Varanasi INDIA
2. Banaras Hindu University Faculty of Science Chemistry Institute of Science 221005 Varanasi INDIA
Abstract
A novel I2‐DMSO‐mediated cascade cyclization approach for synthesizing 2‐hydroxy‐pyrrol‐3(2H)‐one scaffold from readily accessible β‐ketosulfoxonium ylides and β‐enaminone derivatives has been developed. Under metal‐free and mild conditions, this cascade transformation facilitates the formation of one C‐C bond and one C‐N bond in a single reaction vessel, exhibiting a wide range of functional group compatibility. In addition, this method added an active hydroxyl group to a quaternary carbon center.
Subject
Organic Chemistry,Physical and Theoretical Chemistry