Affiliation:
1. Département de Chimie Laboratoire de Chimie Bio-Organique University of Namur (FUNDP) Rue de Bruxelles 61 5000 Namur Belgium
2. ORA-Neptis Rue de la Salette 15 5600 Neuville Belgium
Abstract
Abstract2‐Nitroimidazole based PET tracers are widely used for non‐invasive hypoxic tumor diagnosis. In this context, we report here a general method based on a central Mitsunobu reaction to easily access 2‐nitroimidazole precursors. Optimization of fluorination conditions is described and successfully applied to the radiofluorination of the 2‐nitroimidazole precursors. Moreover, the radiosynthesis of a new potential hypoxia PET tracer is also described. Finally, this article presents a SFC analytical method allowing both an easy monitoring of the fluorination reactions and the measurement of partition coefficients (logP).
Subject
Organic Chemistry,Physical and Theoretical Chemistry