Affiliation:
1. Institute of Applied Synthetic Chemistry TU Wien Getreidemarkt 9/163-OC 1060 Vienna Austria
2. Institute of Chemical Technologies and Analytics TU Wien Getreidemarkt 9/164 1060 Vienna Austria
Abstract
AbstractHerein, we report a ruthenium‐catalyzed ketone directed ortho‐arylation wherein the addition of a bidentate NC‐type ligand, most effectively 2‐(o‐tolyl) pyridine, significantly enhances the C−H arylation reaction. Various aryl‐alkyl ketones, including cyclic, aliphatic, and heterocyclic ones, are competent substrates, and arylboronic acid esters were used as aryl sources. However, substitution with OMe and CF3 in the aromatic ring of the ketone substrates is not tolerated, while such residues on the benzoic ester are possible. Notably, this study provides valuable insights into ketone‐directed ortho arylation in the presence of 2‐(o‐tolyl) pyridine and adds additional options for catalyst and ligand optimization in ruthenium‐catalyzed C−H functionalization.
Subject
Organic Chemistry,Physical and Theoretical Chemistry