Affiliation:
1. Departamento de Química Orgánica e Inorgánica Instituto Universitario de Química Organometálica “Enrique Moles” Julian Clavería 8 33006 Oviedo Spain
Abstract
AbstractGold‐catalyzed cycloisomerization reaction of 1‐bromoalkynes allowed for the preparation of a variety of 1‐bromocyclopentene derivatives. These have been used as substrates in a 3‐step synthetic sequence comprising a cross‐coupling reaction, followed by ozonolysis, and final condensation towards the corresponding 2,5‐disubstituted pyridine. In addition, bicyclic fused pyridines are achieved, including the first total synthesis of the natural product Sinensine B.
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Cited by
4 articles.
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