An Aggregation‐Induced Emission‐Based Fluorescence Turn‐On Probe for Efficient Detection of HS− in Water, Wine, and Living Cells

Abstract

AbstractHydrogen sulfide (H2S), as one of the important endogenous biological regulators, plays a critical role in mediating a wide range of physiological processes. The development of rapid, sensitive, and reliable detection techniques for H2S would be highly appealing. In this paper, a new type of AIE‐based fluorescence turn‐on probe TPA‐M for the detection of H2S has been constructed, involved the rapid release of AIE‐based fluorophore TPA‐CHO with a remarkable fluorescence turn‐on phenomenon in THF/H2O (2/8, v/v, HEPES=20 μM, pH=7.3) medium, exhibiting the attractive advantages such as high sensitivity with the detection limit as low as 1.92×10−3 ppm, excellent selectivity over other anion analytes and biothiols, significant anti‐interference ability and fast response time (within 10 min). What's more, the practical application evaluation indicated that the probe TPA‐M could be efficiently employed in imaging exogenously added H2S in living MCF‐7 cells and detecting H2S in actual water and wine samples.