Straightforward Synthesis of 1‐aryloxy‐1,1‐difluoro‐3‐aminopropan‐2‐ols – Accessing Fluorinated Derivatives of Commercialized Beta‐Blockers

Author:

Moritz Jan‐Ole1,Liu Shuang12,Konieczny Katharina1,Michalik Dirk13,Kragl Udo13,Neumann Helfried1,Beller Matthias1ORCID

Affiliation:

1. Leibniz-Institut für Katalyse e.V. Albert-Einstein-Straße 29a 18059 Rostock Germany

2. School of Chemistry and Chemical Engineering Shanghai University of Engineering Science 333 Longteng Road Songjiang District, Shanghai 201620 China

3. Institut für Chemie Universität Rostock Albert-Einstein-Straße 3a 18059 Rostock Germany

Abstract

AbstractThe efficient synthesis of an array of 1‐aryloxy‐1,1‐difluoro‐3‐aminopropan‐2‐ols in a one‐pot epoxidation/nucleophilic ring‐opening via the corresponding iodohydrines is described. This methodology permits the construction of 1,1‐difluorinated derivatives of commercialized beta‐blockers in addition to unprecedented members of this compound class.

Funder

Leibniz-Gemeinschaft

Publisher

Wiley

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