Straightforward Synthesis of 1‐aryloxy‐1,1‐difluoro‐3‐aminopropan‐2‐ols – Accessing Fluorinated Derivatives of Commercialized Beta‐Blockers-Reference-Cited by-同舟云学术

Straightforward Synthesis of 1‐aryloxy‐1,1‐difluoro‐3‐aminopropan‐2‐ols – Accessing Fluorinated Derivatives of Commercialized Beta‐Blockers

Published:2024-07-11 Issue: Volume: Page:
ISSN:1434-193X
Container-title:European Journal of Organic Chemistry
language:en
Short-container-title:Eur J Org Chem

Author:

Moritz Jan‐Ole¹,Liu Shuang¹²,Konieczny Katharina¹,Michalik Dirk¹³,Kragl Udo¹³,Neumann Helfried¹,Beller Matthias¹^ORCID

Affiliation:

1. Leibniz-Institut für Katalyse e.V. Albert-Einstein-Straße 29a 18059 Rostock Germany

2. School of Chemistry and Chemical Engineering Shanghai University of Engineering Science 333 Longteng Road Songjiang District, Shanghai 201620 China

3. Institut für Chemie Universität Rostock Albert-Einstein-Straße 3a 18059 Rostock Germany

Abstract

AbstractThe efficient synthesis of an array of 1‐aryloxy‐1,1‐difluoro‐3‐aminopropan‐2‐ols in a one‐pot epoxidation/nucleophilic ring‐opening via the corresponding iodohydrines is described. This methodology permits the construction of 1,1‐difluorinated derivatives of commercialized beta‐blockers in addition to unprecedented members of this compound class.

Funder

Leibniz-Gemeinschaft

Publisher

Wiley

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