Affiliation:
1. State Key Laboratory of Fine Chemicals Department of Pharmaceutical Sciences, School of Chemical Engineering Dalian University of Technology 2 Linggong Road Dalian 116024 China
2. State Key Laboratory of Fine Chemicals, School of Chemical Engineering Dalian University of Technology 2 Linggong Road Dalian 116024 China
Abstract
AbstractAn efficient and environmentally friendly methodology for 3,3‐dichlorination and 2‐oxidation of indole derivatives is described. Using KI as promotor, MCl (M=K, Na) as chlorine source, and oxone as oxidant, the reaction proceeds smoothly affording various functionalized 3,3‐dichloro‐2‐oxindoles in moderate to excellent yields. This strategy can also be extended to 3‐substituted indoles. With a broad substrate scope, it is a practical approach to 3,3‐disubstituted‐2‐oxindoles.
Funder
Fundamental Research Funds for the Central Universities
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Cited by
1 articles.
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