Development of Configurationally Labile Biaryl Reagents for Atropisomer Synthesis-Reference-Cited by-同舟云学术

Development of Configurationally Labile Biaryl Reagents for Atropisomer Synthesis

Published:2024-06-04 Issue:28 Volume:27 Page:
ISSN:1434-193X
Container-title:European Journal of Organic Chemistry
language:en
Short-container-title:Eur J Org Chem

Author:

Wu Changhui¹,Jin Yang¹,Zhang Xiaoyuan¹,Gao Ruiqi¹,Dou Xiaowei¹^ORCID

Affiliation:

1. Department of Chemistry School of Science China Pharmaceutical University Nanjing 211198 P. R. China

Abstract

AbstractAxially chiral biaryl scaffolds are important in pharmaceuticals, natural products, and asymmetric synthesis. Atroposelective ring‐opening of configurationally labile biaryl reagents via dynamic kinetic asymmetric transformation provides a valuable approach to access axially chiral biaryl atropisomers. This review summarizes seminal contributions and recent advancements on this topic based on the use of different types of configurationally labile biaryl reagents.

Publisher

Wiley

Reference172 articles.

1. Stereodynamic Strategies to Induce and Enrich Chirality of Atropisomers at a Late Stage

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