Affiliation:
1. College of Chemistry and Materials Science Key Laboratory of Analytical Science and Technology of Hebei Province and MOE Key Laboratory of Medicinal Chemistry and Molecular Diagnostics Hebei University Baoding 071002 Hebei Province P. R. China
Abstract
AbstractDisulfide bonds play a critical role in the pharmaceutical and biological properties of peptides. In this work, disulfiram and thiram were investigated to synthesize disulfide bonds in peptides. Excellent purities of single disulfide bond‐containing peptides were achieved with a fast reaction rate. Furthermore, one‐pot regioselective synthesis of two disulfide bonds was successfully achieved by the combination of disulfiram or thiram with trans‐[PtBr2(CN)4]2− under aqueous conditions.
Funder
Natural Science Foundation of Hebei Province
Subject
Organic Chemistry,Physical and Theoretical Chemistry