Affiliation:
1. Fujian Provincial University Engineering Research Center of Green Materials and Chemical Engineering Fujian Engineering Research Center of New Chinese lacquer Material College of Materials and Chemical Engineering Minjiang University Fuzhou 350108 China
2. Key Laboratory of Molecule Synthesis and Function Discovery College of Chemistry Fuzhou University Fuzhou 350108 China
Abstract
AbstractA multicomponent Kröhnke reaction route toward 2‐trifluoromethyl pyridines from reaction of chalcones with easily available and stable 1‐(3,3,3‐trifluoro‐2‐oxopropyl)pyridin‐1‐ium bromide and ammonium acetate is reported. The reaction is found to be general with a range of substituted chalcones, and the applicability of the methodology in gram scale is demonstrated. Preliminary results suggest that this transformation is initiated by 1,4‐Michael addition, followed by inter‐ and intramolecular nucleophilic addition, and elimination.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Fujian Province
Minjiang University