Transition‐Metal‐Free Chemo‐Selective C−C/C−N Bond Formation Reaction for the Highly Efficient Synthesis of Pyrazoles, Pyrazolo fused Pyrimidines and Pyridines

Abstract

AbstractPyrazoles and pyrazolo fused pyrimidines and pyridines are well known for their applications in various fields like pharmaceuticals, agrochemicals and materials sciences. Keeping this in mind herein, we have developed the transition‐metal‐free approach for the chemo‐selective synthesis of the pyrazole and its derivatives from acetopheneones. The selectivity of the reaction can easily be tuned by shifting reaction from acidic to basic medium for the synthesis of pyrazolo‐pyrirmidines and pyrazolo‐pyridines respectively. The reaction shows excellent functional group tolerance in the form of −F, −Cl, −Br, −NMe2, −OH, −OMe, and −B(OH)2 in good yields.