Affiliation:
1. State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000 P. R. China
Abstract
AbstractAu(I) catalysed vinylogous Conia ene reaction was developed to construct the densely functionalized spiro[4.5]‐deca‐1,6‐diene‐8‐ones from easily available 4‐alkyne tethered cyclohex‐2‐enones. 17 substrates with multiple substitutes on the cyclohex‐2‐enone ring were explored to afford the corresponding spiro[4.5]in 52–81 % yields. This reaction features mild conditions, wide substrate scope and atom economic characters.
Funder
National Natural Science Foundation of China
Subject
Organic Chemistry,Physical and Theoretical Chemistry