Amidyl Radical Directed <i>γ</i>‐C(sp<sup>3</sup>)−H Functionalization with Silyl Enol Ethers via Photoredox Catalysis-Reference-Cited by-同舟云学术

Amidyl Radical Directed γ‐C(sp³)−H Functionalization with Silyl Enol Ethers via Photoredox Catalysis

Published:2023-07-12 Issue:31 Volume:26 Page:
ISSN:1434-193X
Container-title:European Journal of Organic Chemistry
language:en
Short-container-title:Eur J Org Chem

Author:

Xu Kedong¹,Yang Jiawen¹,Qin Haitao¹,Liu Feng¹²^ORCID

Affiliation:

1. Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Medicinal Chemistry College of Pharmaceutical Sciences Soochow University 199 Ren-Ai Road Suzhou Jiangsu 215123 P. R. China

2. Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development College of Pharmaceutical Sciences Soochow University 199 Ren-Ai Road Suzhou Jiangsu 215123 P. R. China

Abstract

AbstractHerein we reported an efficient photoredox‐catalyzed reaction for site‐selective C(sp3)−H functionalization of carboxamides with silyl enol ethers as radical acceptors. The reaction proceeded through amidyl radical‐directed 1,5‐hydrogen atom transfer (1,5‐HAT) and C(sp3)−C(sp3) bond formation via radical addition of silyl enol ethers. The process features mild conditions and high functional‐group tolerance, allowing the preparation of a series of carboxamides with pendant carbonyl moieties.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Organic Chemistry,Physical and Theoretical Chemistry

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