Affiliation:
1. Key Laboratory of Chemical Biology of Hebei Province College of Chemistry and material Science Hebei University Baoding Hebei 071002 P. R. China
2. College of Life Sciences Hebei University Baoding Hebei 071002 P. R. China
3. College of Chemistry and Chemical Engineering Xingtai University Xingtai Hebei 054001 P. R. China
Abstract
AbstractAn efficient and simple one‐pot synthesis of structurally diverse novel tetrahydroquinoline‐fused iminosugars was developed through the aza‐Diels‐Alder mechanism. The adaptability of this method has been demonstrated by a variety of imines and d/l‐ribose tosylates, and both, electron‐donating and ‐withdrawing substituted imines proceed well. In addition, this reaction is characterized by simple operation, good yield, and high atom economy. Some synthetic iminosugars showed moderate anti proliferation of HCT116 tumor cells.
Funder
National Natural Science Foundation of China
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Cited by
3 articles.
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