Affiliation:
1. State Key Laboratory of Medical Chemical Biology and College of Pharmacy Nankai University 38 Tongyan Road, Jinnan District Tianjin 300350 P. R. China
Abstract
AbstractThe synthesis of P‐stereogenic phosphorus compounds has gained considerable attention due to their wide applications across many research fields. Among the available strategies, transition metal‐catalyzed asymmetric transformation of pentavalent phosphoryl (H−P(O)) precursors is particularly appealing. This approach involves a direct C−P bond‐forming process, rendering it straightforward, and it employs readily available, bench‐stable H−P(O) reagents that are compatible with various metal catalysts. Recent years have witnessed significant progress in this field, with a primary focus on asymmetric C−P cross‐couplings and hydrophosphorylations. This Concept article provides a brief summary of recent progress, highlights existing challenges, and discusses future directions in this exciting area.
Funder
National Natural Science Foundation of China
Fundamental Research Funds for the Central Universities
Nankai University
Subject
Organic Chemistry,Physical and Theoretical Chemistry