Affiliation:
1. Department of Chemistry Indian Institute of Science Education and Research (IISER) Tirupati Venkatagiri Road Yerpedu Mandal, Tirupati District, Andhra Pradesh 517619 India
2. Department of Chemistry Indian Institute of Technology Tirupati Yerpedu-Venkatagiri Road, Yerpedu Post Tirupati District, Andhra Pradesh 517619 India
Abstract
AbstractCarbazole derivatives are vital in medicinal and materials chemistry, yet accessing diverse substitutions remains challenging. Here, we introduce a regioselective approach for C1 and C8 alkynylation of carbazoles via palladium‐catalyzed C−H activation. This method provides a direct route to mono‐ and di‐alkynylated derivatives, addressing the scarcity of alkynylated carbazole‐based materials. Our study broadens the synthetic toolbox for carbazole functionalization, offering potential applications in optoelectronics, bio‐imaging, and beyond, while contributing to developing sustainable C−H activation methodologies.
Funder
Indian Institute of Technology Tirupati