Affiliation:
1. College of Chemistry and Molecular Sciences Henan University Kaifeng 475004 P. R. China
2. National & Local Joint Engineering Research Center for the Exploitation of Homology Resources of Southwest Medicine and Food Guizhou University Guiyang 550025 P. R. China
Abstract
AbstractQuinobenzazepines are useful in medicinal chemistry, but their synthesis is very challenging. Herein, we designed and synthesized a range of multi‐functional chalcone‐based quinolinium salts; their synthetic application in the rapid and straightforward construction of quinobenzazepines was successfully explored. A wide range of oxa‐bridged quinobenzazepine polycycles were afforded serendipitously through a dearomative cascade reaction of our newly developed quinolinium salts and acetylacetone. This synthetic strategy features high bond‐ and ring‐forming efficiency and complete regio‐ and diastereoselective control.
Funder
National Natural Science Foundation of China
China Postdoctoral Science Foundation
Subject
Organic Chemistry,Physical and Theoretical Chemistry