Catalyst‐ and Oxidant‐Free Electrochemical Regioselective Halogenation and Trifluoromethylation of 4<i>H</i>‐Pyrido[1,2‐<i>a</i>]pyrimidin‐4‐ones-Reference-Cited by-同舟云学术

Catalyst‐ and Oxidant‐Free Electrochemical Regioselective Halogenation and Trifluoromethylation of 4H‐Pyrido[1,2‐a]pyrimidin‐4‐ones

Published:2023-07-10 Issue:29 Volume:26 Page:
ISSN:1434-193X
Container-title:European Journal of Organic Chemistry
language:en
Short-container-title:Eur J Org Chem

Author:

Su Meiyun¹,Guo Lina¹,Mao Peiyu¹,Xiao Meng¹,Liu Wenjie¹²^ORCID,Wang Shaohua¹²

Affiliation:

1. School of Chemistry and Chemical Engineering Guangdong Pharmaceutical University Guangzhou 510006 P.R. China

2. Guangdong Cosmetics Engineering & Technology Research Center Guangzhou 510006 P.R. China

Abstract

AbstractThe catalyst‐free electrochemical halogenation and trifluoromethylation of 4H‐pyrido[1,2‐a]pyrimidin‐4‐ones was realized under external‐oxidant‐free conditions. This strategy provides an easy and green access to functionalized new 4H‐pyrido[1,2‐a]pyrimidin‐4‐one derivatives with broad scope, good functional group tolerance and high regioselectivity.

Publisher

Wiley

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference75 articles.

2. An Improved and Efficient Process for the Production of Highly Pure Paliperidone, a Psychotropic Agent, via DBU Catalyzed N-Alkylation

3. Scaffold-hopping of bioactive flavonoids: Discovery of aryl-pyridopyrimidinones as potent anticancer agents that inhibit catalytic role of topoisomerase IIα

4. Structure activity relationship studies of 3-arylsulfonyl-pyrido[1,2-a]pyrimidin-4-imines as potent 5-HT6 antagonists

5. Pyrido[1,2-a]pyrimidin-4-one Derivatives as a Novel Class of Selective Aldose Reductase Inhibitors Exhibiting Antioxidant Activity

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