Three Component Synthesis of 4‐Aryl‐2‐aminothiazoles under Transition‐Metal Free Conditions

Author:

Cheng Xi1,Qin Da‐Bin2,Dong Zhi‐Bing1234ORCID

Affiliation:

1. School of Chemistry and Environmental Engineering Wuhan Institute of Technology Wuhan 430205 P. R. China

2. Key Laboratory of Chemical Synthesis and Pollution Control of Sichuan Province School of Chemistry and Chemical Engineering China West Normal University Nanchong 637002 P. R. China

3. School of Chemistry and Chemical Engineering Henan Normal University Xinxiang 453007 P. R. China

4. Key Laboratory of Green Chemical Process Ministry of Education Wuhan Institute of Technology Wuhan 430205 P. R. China

Abstract

AbstractAn efficient three‐component synthesis of 4‐aryl‐2‐aminothiazoles was reported. Phenyl‐thioureas reacted with 2‐bromoacetophenones to form 4‐aryl‐2‐aminothiazoles through cyclization, and the subsequent C−N bonding with benzyl/allyl bromides gave the desired disubstituted thiazoles smoothly. The protocol features transition‐metal free, short reaction time, easily available starting materials, good yields and broad substrate scope, showing potential synthetic value for the synthesis of a variety of biologically or pharmaceutically active compounds.

Publisher

Wiley

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

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