Three‐Component Reactions of 2,2,2‐Trifluoroethyl Ketones, Aryl Azides and Aqueous Ammonia for the Synthesis of 4‐Cyano‐1,2,3‐triazoles-Reference-Cited by-同舟云学术

Three‐Component Reactions of 2,2,2‐Trifluoroethyl Ketones, Aryl Azides and Aqueous Ammonia for the Synthesis of 4‐Cyano‐1,2,3‐triazoles

Published:2023-12-18 Issue:1 Volume:27 Page:
ISSN:1434-193X
Container-title:European Journal of Organic Chemistry
language:en
Short-container-title:Eur J Org Chem

Author:

Gao Ge¹,Lv Leiyang¹^ORCID,Li Zhiping¹

Affiliation:

1. Key Laboratory of Advanced Light Conversion Materials and Biophotonics Department of Chemistry Renmin University of China Beijing 100872 P. R. China

Abstract

AbstractA new method for the synthesis of 4‐cyano‐1,2,3‐triazoles is developed using a three‐component strategy. The cyano group is generated in situ by the reaction of 2,2,2‐trifluoroethyl ketone and aqueous ammonia. The one‐pot protocol allows the synthesis of 4‐cyano‐1,2,3‐triazoles under mild reaction conditions.

Funder

National Natural Science Foundation of China

Renmin University of China

Publisher

Wiley

Subject

Organic Chemistry,Physical and Theoretical Chemistry

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3. Mesoionic and Related Less Heteroatom-Stabilized N-Heterocyclic Carbene Complexes: Synthesis, Catalysis, and Other Applications

4. 1H-1,2,3-Triazol-5-ylidenes: Readily Available Mesoionic Carbenes

5. Ruthenium-Catalyzed Azide Alkyne Cycloaddition Reaction: Scope, Mechanism, and Applications

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