Metal‐Free Regioselective Chlorosulfenylation of Indoles by Dimethylsulfoxide and 1,2‐Dichloroethane-Reference-Cited by-同舟云学术

Metal‐Free Regioselective Chlorosulfenylation of Indoles by Dimethylsulfoxide and 1,2‐Dichloroethane

Published:2024-02-20 Issue:16 Volume:27 Page:
ISSN:1434-193X
Container-title:European Journal of Organic Chemistry
language:en
Short-container-title:Eur J Org Chem

Author:

Palit Kuntal¹,Panda Niranjan¹^ORCID

Affiliation:

1. Department of Chemistry National Institute of Technology Rourkela Odisha India- 769008

Abstract

AbstractDirect chloromethylthiolation of the C(sp2)−H bonds of indole was achieved with the commonly used solvents dimethyl sulfoxide (DMSO) and dichloroethane (DCE). Initially, chlorodimethylsulfonium ion is generated in situ from the reaction of DMSO and DCE on simple heating at 120 °C and is used for electrophilic methylthiolation followed by chlorination, enabling the synthesis of 2‐chloro‐3‐methylthioindoles.

Funder

Science and Engineering Research Board

Publisher

Wiley

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