Gram-Scale Synthesis of Tomatidine, a Steroid Alkaloid with Antibiotic Properties Against Persistent Forms of Staphylococcus aureus
Author:
Affiliation:
1. Institut de Pharmacologie de Sherbrooke; Université de Sherbrooke; 3001, 12th Avenue N J1H 5N4 Sherbrooke Quebec Canada
2. Département de Biologie; Université de Sherbrooke; 2500 Boul. de l'Université J1K 2X9 Sherbrooke Québec Canada
Funder
Cystic Fibrosis Canada
Aligo Innovation
Proteo
Publisher
Wiley
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/ejoc.202000051/fullpdf
Reference39 articles.
1. 2017 Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics https://www.who.int/medicines/publications/WHO-PPL-Short_Summary_25Feb-ET_NM_WHO.pdf
2. Methicillin-resistant Staphylococcus aureus (MRSA): antibiotic-resistance and the biofilm phenotype
3. Frequency of small-colony variants and antimicrobial susceptibility of methicillin-resistant Staphylococcus aureus in cystic fibrosis patients
4. Small colony variants: a pathogenic form of bacteria that facilitates persistent and recurrent infections
5. Alternative Evolutionary Pathways for Drug-Resistant Small Colony Variant Mutants in Staphylococcus aureus
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1. From garden to lab: C-3 chemical modifications of tomatidine unveil broad-spectrum ATP synthase inhibitors to combat bacterial resistance;European Journal of Medicinal Chemistry;2023-12
2. From Garden to Lab: C-3 Chemical Modifications of Tomatidine Unveil Broad-Spectrum Atp Synthase Inhibitors to Combat Bacterial Resistance;2023
3. Divergent Asymmetric Synthesis of Panowamycins, TM‐135, and Veramycin F Using C−H Insertion with Donor/Donor Carbenes;Angewandte Chemie International Edition;2022-04-25
4. Divergent Asymmetric Synthesis of Panowamycins, TM‐135, and Veramycin F Using C−H Insertion with Donor/Donor Carbenes;Angewandte Chemie;2022-04-25
5. The steroidal alkaloids α-tomatine and tomatidine: Panorama of their mode of action and pharmacological properties;Steroids;2021-12
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