Affiliation:
1. Chemistry Department Krishnath College Murshidabad West Bengal 742101 India
Abstract
AbstractHigher carbon saccharide 3‐deoxy‐d‐manno‐oct‐2‐ulosonic acid (Kdo) is a structural unit of bacterial lipopolysaccharides (LPSs) and capsular polysaccharides (CPSs). Kdo is present in the inner core region of LPSs, and this region is structurally conserved. Being non‐mammalian in origin, Kdos are effectively recognized by the native and adaptive immune systems. Therefore, the synthesis of new Kdo derivatives and neoglycoconjugates is highly important for the development of vaccines. This review highlights recent accomplishments related to α‐glycosylations, β‐glycosylations and C‐glycosylations of Kdos and their application to the stereoselective synthesis of inner core oligosaccharides.
Funder
Science and Engineering Research Board
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Cited by
2 articles.
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