Affiliation:
1. Department of Chemistry University of Turin Via Giuria 7 10125 Turin Italy) For computational data corresponds to:On the pdf this part underlined in yellow appears as: For computational data corresponds to: giovanniWe would like it to be: For computational data corresponds to
Abstract
AbstractA mild and catalyst‐free protocol to obtain several 2‐chloromethylpyrrolidines by the use of a commercial solution of sodium hypochlorite is here reported, without the need for a light source. The choice of the solvent revealed to be crucial in the success of the reaction. Mechanistic studies, both experimental and computational, confirmed a radical mechanism, where the deprotonation step, followed by the oxidation of a N‐centered anion to the corresponding radical, allowed 2‐chloromethylpyrrolidines, by a very fast cyclization, to be obtained. Sodium hypochlorite plays the role of both the oxidant and the chlorine source.
Funder
Ministero dell'Università e della Ricerca