Affiliation:
1. Department of Applied Chemistry Anhui Agricultural University Hefei Anhui 230036 P. R. China
Abstract
AbstractA new synthetic approach to novel axially chiral iodobenzocarbazole derivatives based on the highly enantioselective intramolecular iodoarylation of linked alkyne‐indole systems was developed by using the versatile chiral catalyst, stereogenic‐at‐cobalt(III)‐complex, through an axially chiral iodinated vinylidene o‐quinone methide (IVQM) intermediate. This protocol provides 21 examples in excellent yields with good to high enantioselectivities (up to 96 % yield, 98 % ee). Furthermore, the introduced iodine atoms can easily be converted into other functional groups.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Anhui Province
Anhui Agricultural University
Subject
Organic Chemistry,Physical and Theoretical Chemistry