Synthesis of Alkaloids and Compounds Containing the 3,4‐Benzomorphan Scaffold

Abstract

AbstractSeveral natural products, bearing an embedded hexahydro‐2,6‐methano‐1‐benzazocine framework (3,4‐benzomorphan) – a heterocyclic regioisomer of the 6,7‐benzomorphan substructure found in morphine alkaloids, have therapeutic potential for a variety of diseases. Biogenesis, biosynthetic approaches, and total syntheses of alkaloids or synthetic azapolycyclic compounds featuring the aforementioned azatricyclic ring system (i. e., a 3,4‐benzomorphan scaffold) are reviewed.