Naturally Occurring Genetic Variants of Human Caspase-1 Differ Considerably in Structure and the Ability to Activate Interleukin-1β-Reference-Cited by-同舟云学术

Naturally Occurring Genetic Variants of Human Caspase-1 Differ Considerably in Structure and the Ability to Activate Interleukin-1β

Published:2012-08-10 Issue:1 Volume:34 Page:122-131
ISSN:1059-7794
Container-title:Human Mutation
language:en
Short-container-title:Human Mutation

Author:

Luksch Hella¹,Romanowski Michael J.²,Chara Osvaldo³,Tüngler Victoria¹,Caffarena Ernesto R.⁴,Heymann Michael C.¹,Lohse Peter⁵,Aksentijevich Ivona⁶,Remmers Elaine F.⁶,Flecks Silvana¹,Quoos Nadine¹,Gramatté Johannes¹,Petzold Cathleen¹,Hofmann Sigrun R.¹,Winkler Stefan¹,Pessler Frank,Kallinich Tilmann⁷,Ganser Gerd⁸,Nimtz-Talaska Antje⁹,Baumann Ulrich¹⁰,Runde Volker¹¹,Grimbacher Bodo¹²,Birmelin Jennifer¹²,Gahr Manfred¹,Roesler Joachim¹,Rösen-Wolff Angela¹

Affiliation:

1. Department of Pediatrics; University Hospital Carl Gustav Carus; Dresden; Germany

2. Department of Structural Biology; Sunesis Pharmaceuticals, Inc.; South San Francisco; California

3. Instituto de Física de Fluidos y Sistemas Biológicos (IFLYSIB), CONICET,; University of La Plata (UNLP), 59-789 B1900BTE La Plata, Argentina; Center for Information Services and High-Performance Computing; Technische Universität Dresden; Dresden; Germany

4. Programa de Computação Científica; Fundação Oswaldo Cruz, FIOCRUZ/MS; Manguinhos; Brazil

5. Department of Clinical Chemistry; Ludwig-Maximilians-University; Munich; Germany

6. Inflammatory Disease Section; NHGRI, NIH; Bethesda; Maryland

7. Department for Pediatric Pneumology and Immunology; Charité Medical University of Berlin; Berlin; Germany

8. St. Josef-Stift; Sendenhorst; Germany

9. Kinderrheumatologie, Ärztehaus, Frankfurt/Oder; Germany

10. Paediatric Pulmonology, Allergology and Neonatology; Hannover Medical School; Hannover; Germany

11. Wilhelm-Anton-Hospital; Goch; Germany

12. Centre of Chronic Immunodeficiency; University Hospital Freiburg; Freiburg; Germany

Publisher

Wiley

Subject

Genetics (clinical),Genetics

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/humu.22169/fullpdf

Reference44 articles.

1. The efficacy of anakinra in an adolescent with colchicine-resistant familial Mediterranean fever;Calligaris;Eur J Pediatr,2008

2. Unraveling hot spots in binding interfaces: progress and challenges;DeLano;Curr Opin Struct Biol,2002

3. Interleukin-1beta;Dinarello;Crit Care Med,2005

4. A clinical perspective of IL-1beta as the gatekeeper of inflammation;Dinarello;Eur J Immunol,2011

5. Accurate bond and angle parameters for X-ray protein structure refinement;Engh;Acta Crystallogr. A,1991

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