The 2023 Orthopedic Research Society's international consensus meeting on musculoskeletal infection: Summary from the in vitro section-Reference-Cited by-同舟云学术

The 2023 Orthopedic Research Society's international consensus meeting on musculoskeletal infection: Summary from the in vitro section

Published:2024-01-12 Issue: Volume: Page:
ISSN:0736-0266
Container-title:Journal of Orthopaedic Research
language:en
Short-container-title:Journal Orthopaedic Research

Author:

Hickok Noreen J.¹^ORCID,Li Bingyun²^ORCID,Oral Ebru³^ORCID,Zaat Sebastian A. J.⁴^ORCID,Armbruster David A.⁵,Atkins Gerald J.⁶^ORCID,Chen Antonia F.⁷^ORCID,Coraça‐Huber Débora C.⁸^ORCID,Dai Tianhong⁹,Greenfield Edward M.¹⁰,Kasinath Rajendra¹¹,Libera Matthew¹²,Marques Cláudia N. H.¹³,Moriarty T. Fintan¹⁴^ORCID,Scott Phillips K.¹⁵,Raghuraman Kapil¹⁶,Ren Dacheng¹⁷,Rimondini Lia¹⁸,Saeed Kordo¹⁹²⁰^ORCID,Schaer Thomas P.²¹^ORCID,Schwarz Edward M.²²^ORCID,Spiegel Christopher²³,Stoodley Paul²⁴^ORCID,Truong Vi Khanh²⁵,Tsang Shao‐Ting Jerry²⁶,Wildemann Britt²⁷^ORCID,Zelmer Anja R.⁶,Zinkernagel Annelies S.²⁸

Affiliation:

1. Department of Orthopaedic Surgery, Department of Biochemistry & Molecular Biology Thomas Jefferson University Philadelphia Pennsylvania USA

2. Department of Orthopaedics, School of Medicine West Virginia University Morgantown West Virginia USA

3. Harris Orthopaedic Laboratory, Department of Orthopaedic Surgery, Harvard Medical School Massachusetts General Hospital Boston Massachusetts USA

4. Department of Medical Microbiology and Infection Prevention, Amsterdam Institute for Infection and Immunity, Amsterdam UMC University of Amsterdam Amsterdam The Netherlands

5. DePuy Synthes Biomaterials West Chester Pennsylvania USA

6. Centre for Orthopaedic and Trauma Research University of Adelaide Adelaide South Australia Australia

7. Department of Orthopaedics, Brigham and Women's Hospital Harvard Medical School Boston Massachusetts USA

8. Research Laboratory for Implant Associated Infections (Biofilm Lab), University Hospital for Orthopedics and Traumatology, Experimental Orthopaedics Medical University of Innsbruck Innsbruck Austria

9. Harvard Medical School, Wellman Center for Photomedicine Massachusetts General Hospital Boston Massachusetts USA

10. Department of Orthopaedic Surgery, Indiana University School of Medicine Indiana Center for Musculoskeletal Health Indianapolis Indiana USA

11. DePuy Synthes Biomaterials Warsaw Indiana USA

12. Department of Chemical Engineering and Materials Science Stevens Institute of Technology Hoboken New Jersey USA

13. Department of Biological Sciences, Binghamton Biofilm Research Center Binghamton University Binghamton New York USA

14. AO Research Institute Davos Davos Switzerland

15. Laboratory of Analytical Chemistry, Division of Biological Standards and Quality Control, Office of Compliance and Biologics Quality, Center for Biologics Evaluation and Research US Food and Drug Administration Silver Spring Maryland USA

16. Enovis Austin Texas USA

17. Department of Biomedical and Chemical Engineering Syracuse University Syracuse New York USA

18. Department of Health Sciences Università del Piemonte Orientale Novara Italy

19. University Hospital Southampton NHS Foundation Trust Winchester and Basingstoke UK

20. University of Southampton Southampton UK

21. Department of Clinical Studies, New Bolton Center University of Pennsylvania Kennett Square Pennsylvania USA

22. Center for Musculoskeletal Research University of Rochester Rochester New York USA

23. Research Laboratory for Biofilms and Implant Associated Infections (BIOFILM LAB), Experimental Orthopedics, University Hospital for Orthopedics and Traumatology Medical University of Innsbruck Innsbruck Austria

24. Department Microbial Infection and Immunity and Department of Orthopaedics The Ohio State University Columbus Ohio USA

25. Biomedical Nanoengineering Laboratory College of Medicine and Public Health Bedford Park South Australia Australia

26. Department of Trauma and Orthopaedic Surgery University of Edinburgh Edinburgh Scotland UK

27. Experimental Trauma Surgery, Department of Trauma, Hand and Reconstructive Surgery, Jena University Hospital Friedrich Schiller University Jena Jena Germany

28. Department of Infectious Diseases and Hospital Epidemiology University Hospital of Zurich and University of Zurich Zurich Switzerland

Abstract

AbstractAntimicrobial strategies for musculoskeletal infections are typically first developed with in vitro models. The In Vitro Section of the 2023 Orthopedic Research Society Musculoskeletal Infection international consensus meeting (ICM) probed our state of knowledge of in vitro systems with respect to bacteria and biofilm phenotype, standards, in vitro activity, and the ability to predict in vivo efficacy. A subset of ICM delegates performed systematic reviews on 15 questions and made recommendations and assessment of the level of evidence that were then voted on by 72 ICM delegates. Here, we report recommendations and rationale from the reviews and the results of the internet vote. Only two questions received a ≥90% consensus vote, emphasizing the disparate approaches and lack of established consensus for in vitro modeling and interpretation of results. Comments on knowledge gaps and the need for further research on these critical MSKI questions are included.

Publisher

Wiley

Subject

Orthopedics and Sports Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jor.25774

Reference21 articles.

1. 2018 international consensus meeting on musculoskeletal infection: Summary from the biofilm workgroup and consensus on biofilm related musculoskeletal infections

2. Challenges in linking preclinical anti-microbial research strategies with clinical outcomes for device-associated infections

3. Sterilization of implantable polymer-based medical devices: A review

4. Optimizing the sterilization of PLGA scaffolds for use in tissue engineering

5. Ecology of mixed biofilms subjected daily to a chlorinated alkaline solution: spatial distribution of bacterial species suggests a protective effect of one species to another