Noninvasive exosomal proteomic biosignatures, including cystatin SN, peroxiredoxin-5, and glycoprotein VI, accurately predict chronic rhinosinusitis with nasal polyps

Author:

Mueller Sarina K.123,Nocera Angela L.12,Dillon Simon T.2456,Gu Xuesong2456,Wendler Olaf3,Otu Hasan H.7,Libermann Towia A.2456,Bleier Benjamin S.12

Affiliation:

1. Department of Otolaryngology; Massachusetts Eye and Ear Infirmary; Boston MA

2. Harvard Medical School; Boston MA

3. Department of Otorhinolaryngology, Head and Neck Surgery; Friedrich-Alexander University Erlangen-Nürnberg; Erlangen Germany

4. Department of Medicine; Beth Israel Deaconess Medical Center; Boston MA

5. Division of Interdisciplinary Medicine and Biotechnology; Beth Israel Deaconess Medical Center; Boston MA

6. Genomics, Proteomics; Bioinformatics and Systems Biology Center Beth Israel Deaconess Medical Center; Boston MA

7. Department of Electrical and Computer Engineering; University of Nebraska-Lincoln; Lincoln NE

Publisher

Wiley

Subject

Otorhinolaryngology,Immunology and Allergy

Reference50 articles.

1. Intracranial complications of sinusitis;Giannoni;Laryngoscope,1997

2. Prevalence of asthma, aspirin intolerance, nasal polyposis and chronic obstructive pulmonary disease in a population-based study;Hedman;Int J Epidemiol,1999

3. Prevalence of nasal polyposis in France: a cross-sectional, case-control study;Klossek;Allergy,2005

4. Total and specific IgE in nasal polyps is related to local eosinophilic inflammation;Bachert;J Allergy Clin Immunol,2001

5. International consensus statement on allergy and rhinology: rhinosinusitis;Orlandi;Int Forum Allergy Rhinol,2016

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