Do pancreatic cancer and chronic pancreatitis share the same genetic risk factors? A PANcreatic Disease ReseArch (PANDoRA) consortium investigation

Author:

Campa Daniele1ORCID,Pastore Manuela12,Capurso Gabriele3,Hackert Thilo4,Di Leo Milena5,Izbicki Jakob R.6,Khaw Kay-Tee7,Gioffreda Domenica8,Kupcinskas Juozas9,Pasquali Claudio10,Macinga Peter11,Kaaks Rudolf12,Stigliano Serena3,Peeters Petra H.1314,Key Timothy J.15,Talar-Wojnarowska Renata16,Vodicka Pavel11,Valente Roberto3,Vashist Yogesh K.617,Salvia Roberto18,Papaconstantinou Ioannis19,Shimizu Yasuhiro20,Valsuani Chiara21,Zambon Carlo Federico22,Gazouli Maria23,Valantiene Irena9,Niesen Willem4,Mohelnikova-Duchonova Beatrice24,Hara Kazuo25,Soucek Pavel26ORCID,Malecka-Panas Ewa16,Bueno-de-Mesquita H. Bas272829,Johnson Theron12,Brenner Herman303132,Tavano Francesca8,Fogar Paola33,Ito Hidemi3435ORCID,Sperti Cosimo10,Butterbach Katja30,Latiano Anna8,Andriulli Angelo8,Cavestro Giulia Martina5,Busch Olivier R.C.36,Dijk Frederike37,Greenhalf William38,Matsuo Keitaro3435ORCID,Lombardo Carlo3940,Strobel Oliver4,König Anna-Katharina4,Cuk Katarina30,Strothmann Hendrik4,Katzke Verena12,Cantore Maurizio21,Mambrini Andrea21,Oliverius Martin41,Pezzilli Raffaele42,Landi Stefano1,Canzian Federico2ORCID

Affiliation:

1. Department of Biology; University of Pisa; Pisa Italy

2. Genomic Epidemiology Group, German Cancer Research Center (DKFZ); Heidelberg Germany

3. Digestive and Liver Disease Unit; S. Andrea Hospital ‘Sapienza’ University of Rome; Rome Italy

4. Department of General Surgery; University Hospital Heidelberg; Heidelberg Germany

5. Gastroenterology and Gastrointestinal Endoscopy Unit; Vita-Salute San Raffaele University, San Raffaele Scientific Institute; Milan Italy

6. Department of General, Visceral and Thoracic Surgery; University Medical Center Hamburg-Eppendorf; Hamburg Germany

7. Clinical Gerontology Unit, Addenbrooke's Hospital; University of Cambridge School of Clinical Medicine; Cambridge United Kingdom

8. Division of Gastroenterology and Research Laboratory, Department of Surgery; IRCCS Scientific Institute and Regional General Hospital “Casa Sollievo della Sofferenza”; San Giovanni Rotondo Italy

9. Department of Gastroenterology; Lithuanian University of Health Sciences; Kaunas Lithuania

10. Department of Surgery, Oncology and Gastroenterology (DiSCOG); University of Padova; Padova Italy

11. Institute of Experimental Medicine, Czech Academy of Sciences and Institute of Clinical and Experimental Medicine; Prague Czech Republic

12. Division of Cancer Epidemiology; German Cancer Research Center (DKFZ); Heidelberg Germany

13. Department of Epidemiology; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht; Utrecht The Netherlands

14. MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health; Imperial College; London United Kingdom

15. Cancer Epidemiology Unit, Nuffield Department of Population Health; University of Oxford; Oxford United Kingdom

16. Department of Digestive Tract Diseases; Medical University of Lodz; Lodz Poland

17. Department of Visceral Surgery; Kantonsspital Aarau AG; Aarau Switzerland

18. Department of Surgery; Pancreas Institute, University and Hospital Trust of Verona; Verona Italy

19. Second Department of Surgery; Aretaieion Hospital, School of Medicine, National and Kapodistrian University of Athens; Athens Greece

20. Department of Gastroenterological Surgery; Aichi Cancer Center Hospital; Nagoya Japan

21. Oncological Department; Azienda USL Toscana Nord Ovest, Oncological Unit of Massa Carrara; Carrara Massa and Carrara Italy

22. Department of Medicine (DIMED); University of Padova; Padova Italy

23. Department of Basic Medical Sciences, Laboratory of Biology, School of Medicine; National and Kapodistrian University of Athens; Athens Greece

24. Department of Oncology; Palacky University Medical School and Teaching Hospital; Olomouc Czech Republic

25. Department of Gastroenterology; Aichi Cancer Center Hospital; Nagoya Japan

26. Biomedical Center, Faculty of Medicine in Pilsen; Charles University in Prague; Pilsen Czech Republic

27. Department for Determinants of Chronic Diseases (DCD); National Institute for Public Health and the Environment; Bilthoven The Netherlands

28. Department of Epidemiology and Biostatistics, The School of Public Health; Imperial College London, St Mary's Campus; London United Kingdom

29. Department of Social & Preventive Medicine, Faculty of Medicine; University of Malaya; Kuala Lumpur Malaysia

30. Division of Clinical Epidemiology; German Cancer Research Center (DKFZ); Heidelberg Germany

31. Division of Preventive Oncology; German Cancer Research Center (DKFZ), and National Center for Tumor Diseases (NCT); Heidelberg Germany

32. German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ); Heidelberg Germany

33. Department of Laboratory Medicine; University-Hospital of Padova; Padova Italy

34. Division of Molecular and Clinical Epidemiology; Aichi Cancer Center Research Institute; Nagoya Japan

35. Department of Epidemiology; Nagoya University Graduate School of Medicine; Nagoya Japan

36. Department of Surgery; Academic Medical Centre; Amsterdam the Netherlands

37. Department of Pathology; Academic Medical Centre; Amsterdam the Netherlands

38. Institute for Health Research, Liverpool Pancreas Biomedical Research Unit, University of Liverpool; Liverpool United Kingdom

39. Division of General and Transplant Surgery; University of Pisa; Pisa Italy

40. Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia; University of Pisa; Pisa Italy

41. Transplant Surgery Department; Institute for Clinical and Experimental Medicine; Prague Czech Republic

42. Pancreas Unit, Department of Digestive Diseases and Internal Medicine Sant'Orsola-Malpighi Hospital; Bologna Italy

Funder

Medical Research Council

The Italian Ministry of Health

Ministry of Youth and Education (COST LD14050)

Czech Ministry of Health

Cancer Research UK

Ministry of Health of the Czech Republic

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference33 articles.

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