Affiliation:
1. Department of Emergency Medicine, Beijing Luhe Hospital Capital Medical University Beijing China
2. Department of Emergency Medicine, Beijing Chao‐Yang Hospital Capital Medical University, & Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation Beijing China
3. Department of Cardiology Institute of Cardiovascular Diseases First Affiliated Hospital of Dalian Medical University Dalian China
Abstract
AbstractThe aim of the meta‐analysis was to generate a more comprehensive understanding of the HFA‐PEFF score in the diagnosis of heart failure with preserved ejection fraction (HFpEF) and to pose clues in the field of scientific and clinical practice. Electronic databases of PubMed, Web of Science, Cochrane Library, and Embase were systematically searched. Studies investigating the use of the HFA‐PEFF score to diagnose HFpEF were included. Pooled sensitivity, specificity, positive likelihood ratio (PLR) and negative Likelihood Ratio (NLR), diagnostic odds ratio (DOR), area under the curve of summary receiver operating characteristic, and superiority index were calculated. Five studies with 1521 participants were included in this meta‐analysis. In the pooled analysis of the ‘Rule‐out’ approach, the pooled sensitivity, specificity, PLR, NLR, and DOR were 0.98 (0.94, 1.00), 0.33 (0.08, 0.73), 1.5 (0.8, 2.5), 0.05 (0.02, 0.17), and 28 (6, 127). In the pooled analysis of the ‘Rule‐in’ approach, the pooled sensitivity and specificity, PLR, NLR, and DOR were 0.69 (0.62, 0.75), 0.87 (0.64, 0.96), 5.5 (1.8, 16.9), 0.35 (0.30, 0.41), and 16 (5, 50). This meta‐analysis indicates that the HFA‐PEFF algorithm showed acceptable specificity and sensitivity for the diagnosis and exclusion of HFpEF. More relevant studies on the diagnostic validity of the HFA‐PEFF score are needed in the future.
Funder
Beijing Municipal Science and Technology Commission
Subject
Cardiology and Cardiovascular Medicine