Time Course for Onset and Recovery from Effects of a Novel Male Reproductive Toxicant: Implications for Apical Preclinical Study Designs

Author:

Powles-Glover Nicola1,Mitchard Terri1,Stewart Jane1

Affiliation:

1. AstraZeneca, Mereside, Alderley Park, Alderley Edge; Macclesfield Cheshire SK10 4TG

Publisher

Wiley

Subject

Health, Toxicology and Mutagenesis,Developmental Biology,Toxicology,Embryology

Reference25 articles.

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2. SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: (1) binding and functional profile;Biton;Neuropsychopharmacology,2007

3. A nicotinic acetylcholine receptor is involved in the acrosome reaction of human sperm initiated by recombinant human ZP3;Bray;Biol Reprod,2002

4. Assessment of fetal exposure risk following seminal excretion of a therapeutic IgG4 (T-IgG4) monoclonal antibody using a rabbit model;Breslin;Science,2014

5. Current developments in reproductive toxicity testing of pesticides;Cooper;Reprod Toxicol,2009

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1. Male premating treatment in FEED studies: Length is not everything;Reproductive Toxicology;2024-12

2. General Design Considerations in Reproductive and Developmental Toxicity Studies;The Quintessence of Basic and Clinical Research and Scientific Publishing;2023

3. The Role of Pathology in Evaluation of Reproductive, Developmental, and Juvenile Toxicity;Haschek and Rousseaux's Handbook of Toxicologic Pathology;2022

4. The relevance of experimental reproductive studies in safety assessment;Current Opinion in Toxicology;2017-04

5. Timing is everything for sperm assessment in fertility studies;Reproductive Toxicology;2016-09

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