Early Vaginal Opening in Juvenile Female Rats Given BRAF-Inhibitor Dabrafenib Is Not Associated with Early Physiologic Sexual Maturation-Reference-Cited by-同舟云学术

Early Vaginal Opening in Juvenile Female Rats Given BRAF-Inhibitor Dabrafenib Is Not Associated with Early Physiologic Sexual Maturation

Published:2015-12 Issue:6 Volume:104 Page:244-252
ISSN:1542-9733
Container-title:Birth Defects Research Part B: Developmental and Reproductive Toxicology
language:en
Short-container-title:Birth Defects Res B

Author:

Posobiec Lorraine M.¹,Vidal Justin D.²,Hughes-Earle Angela¹,Laffan Susan B.¹,Hart Timothy¹

Affiliation:

1. Safety Assessment, GlaxoSmithKline; King of Prussia; Pennsylvania

2. Vet Path Services, Inc; Mason Ohio

Publisher

Wiley

Subject

Health, Toxicology and Mutagenesis,Developmental Biology,Toxicology,Embryology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/bdrb.21165/fullpdf

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2. Selective and potent raf inhibitors paradoxically stimulate normal cell proliferation and tugor Growth;Carnahan;Mol Cancer Ther,2010

3. Urogastrone - epidermal growth factor and aspects of sexual maturation in female rats as a function of age at treatment;da Silva;J Dev Physiol,1991

4. How cutaneous eruptions help to understand the mode of action of kinase inhibitors;Dummer;Br J Dermatol,2012

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