Factors influencing the decision to introduce alternative nutrition in patients with Duchenne muscular dystrophy

Abstract

AbstractIntroduction/AimsNutritional management of adults with Duchenne muscular dystrophy (DMD) is an important clinical issue. However, it is not clear which dysphagia‐related factors should prompt introduction of alternative nutrition (AN). We aimed to determine which patients with DMD were introduced to AN.MethodsThis retrospective study included 56 patients with DMD (median age, 23.5 years). They were divided into patients able to continue oral feeding (OF) and those introduced to AN. Body weight, frequency of ventilator use, daily meals, history of steroid treatment, results of videofluoroscopic examination of swallowing (VF), and awareness of dysphagia were evaluated.ResultsOf 56 patients, 19 were in the AN group. After AN introduction, 93% of the patients continued oral intake. The proportion of patients who consumed chopped and liquid diets was higher, and body weight was lower, in the AN than in the OF group. There were no significant differences in age, upper limb function of feeding, frequency of ventilator use, or history of steroid therapy between the two groups. The frequencies of aspiration and residue in the pyriform sinus in VF were higher in the AN group than in the OF group. Decision‐tree analysis showed that food form and subjective difficulty swallowing solid foods were the most important factors affecting the decision‐making for AN.DiscussionPatients with DMD who had difficulty eating solid foods were started on AN because they were unable to maintain their weight. These findings provide information for future longitudinal studies to assess the value of AN.