Affiliation:
1. Beijing Key Laboratory of Work Safety Intelligent Monitoring School of Electronic Engineering Beijing University of Posts and Telecommunications No.10 Xitucheng Road, Haidian District Beijing 100876 China
2. School of Science Minzu University of China No.27 Zhongguancun South Street, Haidian District Beijing 100081 China
Abstract
AbstractDue to the properties of hypoxia, lower pH, and higher hydrogen peroxide (H2O2) in the tumor microenvironment (TME), a wide variety of metal peroxide nanomaterials have got great attention for efficient TME‐responsive and ‐regulated tumor therapy. However, a single species of metal peroxide is inadequate to realize high effective anticancer therapy. Herein, we have synthesized a hyaluronic acid (HA) modified CaO2/CuO2/Fe3O4 nanocomposite by a simple and flexible strategy. CaO2 can generate H2O2 by reacting with water in slightly acidic TME, and the self‐supplying H2O2 can be catalyzed to generate ⋅OH by both Cu2+ and Fe2+ via Fenton‐type reaction. Strongly oxidizing ⋅OH can induce tumor cells death for enhanced chemodynamic therapy (CDT). The H2O2 self‐supplying and ⋅OH self‐catalyzed nanocomposite exhibited favorable pH‐controlled ⋅OH generation and excellent cancer cells growth inhibition ability, providing a potential nanotheranostics platform with active targeting and favorable therapeutic efficacy in tumor therapy.
Funder
National Natural Science Foundation of China