Joint radial trajectory correction for accelerated T2* mapping on an MR‐Linac

Abstract

AbstractBackgroundT2* mapping can characterize tumor hypoxia, which may be associated with resistance to therapy. Acquiring T2* maps during MR‐guided radiotherapy could inform treatment adaptation by, for example, escalating the dose to resistant sub‐volumes.PurposeThe purpose of this work is to demonstrate the feasibility of the accelerated T2* mapping technique using model‐based image reconstruction with integrated trajectory auto‐correction (TrACR) for MR‐guided radiotherapy on an MR‐Linear accelerator (MR‐Linac).Materials and methodsThe proposed method was validated in a numerical phantom, where two T2* mapping approaches (sequential and joint) were compared for different noise levels (0,0.1,0.5,1) and gradient delays ([1, ‐1] and [1, ‐2] in units of dwell time for x‐ and y‐axis, respectively). Fully sampled k‐space was retrospectively undersampled using two different undersampling patterns. Root mean square errors (RMSEs) were calculated between reconstructed T2* maps and ground truth. In vivo data was acquired twice weekly in one prostate and one head and neck cancer patient undergoing treatment on a 1.5 T MR‐Linac. Data were retrospectively undersampled and T2* maps reconstructed, with and without trajectory corrections were compared.ResultsNumerical simulations demonstrated that, for all noise levels, T2* maps reconstructed with a joint approach demonstrated less error compared to an uncorrected and sequential approach. For a noise level of 0.1, uniform undersampling and gradient delay [1, ‐1] (in units of dwell time for x‐ and y‐axis, respectively), RMSEs for sequential and joint approaches were 13.01 and 9.32 ms, respectively, which reduced to 10.92 and 5.89 ms for a gradient delay of [1, 2]. Similarly, for alternate undersampling and gradient delay [1, ‐1], RMSEs for sequential and joint approaches were 9.80 and 8.90 ms, respectively, which reduced to 9.10 and 5.40 ms for gradient delay [1, 2]. For in vivo data, T2* maps reconstructed with our proposed approach resulted in less artifacts and improved visual appearance compared to the uncorrected approach. For both prostate and head and neck cancer patients, T2* maps reconstructed from different treatment fractions showed changes within the planning target volume (PTV).ConclusionUsing the proposed approach, a retrospective data‐driven gradient delay correction can be performed, which is particularly relevant for hybrid devices, where full information on the machine configuration is not available for image reconstruction. T2* maps were acquired in under 5 min and can be integrated into MR‐guided radiotherapy treatment workflows, which minimizes patient burden and leaves time for additional imaging for online adaptive radiotherapy on an MR‐Linac.