Retinal perfusion is linked to cognition and brain MRI biomarkers in Black Americans

Author:

Abdolahi Farzan1ORCID,Yu Victoria1,Varma Rohit2,Zhou Xiao3,Wang Ruikang K.34,D'Orazio Lina M.5,Zhao Chenyang6,Jann Kay6,Wang Danny J.56,Kashani Amir H.7,Jiang Xuejuan1ORCID

Affiliation:

1. Department of Ophthalmology University of Southern California Keck School of Medicine Los Angeles California USA

2. Southern California Eye Institute CHA Hollywood Presbyterian Medical Center Los Angeles California USA

3. Department of Bioengineering University of Washington Seattle Washington USA

4. Department of Ophthalmology University of Washington Seattle Washington USA

5. Department of Neurology University of Southern California Keck School of Medicine Los Angeles California USA

6. Laboratory of FMRI Technology Stevens Neuroimaging and Informatics Institute University of Southern California Keck School of Medicine Los Angeles California USA

7. Department of Ophthalmology Wilmer Eye Institute Johns Hopkins University School of Medicine Baltimore Maryland USA

Abstract

AbstractIntroductionWe investigated whether retinal capillary perfusion is a biomarker of cerebral small vessel disease and impaired cognition among Black Americans, an understudied group at higher risk for dementia.MethodsWe enrolled 96 Black Americans without known cognitive impairment. Four retinal perfusion measures were derived using optical coherence tomography angiography. Neurocognitive assessment and brain magnetic resonance imaging (MRI) were performed. Multiple linear regression analyses were performed.ResultsLower retinal capillary perfusion was correlated with worse Oral Symbol Digit Test (P < = 0.005) and Fluid Cognition Composite scores (P < = 0.02), but not with the Crystallized Cognition Composite score (P > = 0.41). Lower retinal perfusion was also correlated with higher free water and peak width of skeletonized mean diffusivity, and lower fractional anisotropy (all P < 0.05) on MRI (N = 35).DiscussionLower retinal capillary perfusion is associated with worse information processing, fluid cognition, and MRI biomarkers of cerebral small vessel disease, but is not related to crystallized cognition.

Funder

National Institute on Aging

National Institutes of Health

BrightFocus Foundation

National Eye Institute

Research to Prevent Blindness

Publisher

Wiley

Subject

Psychiatry and Mental health,Cellular and Molecular Neuroscience,Geriatrics and Gerontology,Neurology (clinical),Developmental Neuroscience,Health Policy,Epidemiology

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