Affiliation:
1. School of Materials Science and Engineering Qingdao University of Science and Technology Qingdao PR China
2. School of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao PR China
3. School of Polymer Science and Engineering Qingdao University of Science and Technology Qingdao PR China
Abstract
AbstractDesigning a theranostic probe for noninvasive bone imaging and bone disease therapy is both challenging and desirable. Herein, an ultrasmall Au nanocluster (NC, <2 nm)‐based theranostic probe is developed to achieve highly temporospatial in vivo bone‐targeted photoluminescence (PL) imaging in the second near‐infrared window (NIR‐II) and enhanced rheumatoid arthritis (RA) therapy. The key design of the probe involves the surface phosphorylation of atomically precise NIR‐II emitting Au44 NCs. This phosphorylation enhances the bone‐targeting ability of the probe due to the highly concentrated phosphate groups, allowing the probe to realize in vivo bone‐targeted NIR‐II PL imaging. Moreover, benefiting from the enhanced bone‐targeting ability, ultrasmall hydrodynamic diameter, and excellent anti‐inflammation and immunomodulatory effects, the probe not only demonstrates superior therapeutic efficacy for RA rats, effectively restoring the destructed cartilage to nearly normal but also exhibits good renal clearance and benign biocompatibility. These favorable attributes cannot be achieved by commercial methotrexate used for RA treatment. This study presents a new design paradigm for metal NC‐based theranostic probes, offering the potential for high‐resolution bone‐targeted PL imaging and improved RA therapy.
Funder
National Natural Science Foundation of China
Taishan Scholar Foundation of Shandong Province
Natural Science Foundation of Shandong Province
Subject
General Medicine,General Chemistry
Cited by
1 articles.
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