Insights From Liver‐Humanized Mice on Cholesterol Lipoprotein Metabolism and LXR‐Agonist Pharmacodynamics in Humans

Author:

Minniti Mirko E.1ORCID,Pedrelli Matteo1,Vedin Lise‐Lotte1,Delbès Anne‐Sophie2,Denis Raphaël G.P.2,Öörni Katariina3,Sala Claudia4,Pirazzini Chiara5,Thiagarajan Divya6,Nurmi Harri J.37,Grompe Markus89,Mills Kevin10,Garagnani Paolo111,Ellis Ewa C.S.12ORCID,Strom Stephen C.13,Luquet Serge H.2,Wilson Elizabeth M.9,Bial John9,Steffensen Knut R.1,Parini Paolo11415

Affiliation:

1. Department of Laboratory Medicine Division of Clinical Chemistry Karolinska Institute Stockholm Sweden

2. Unit of Functional and Adaptive Biology Paris Diderot University Sorbonne Paris Cité Paris France

3. Atherosclerosis Research Laboratory Wihuri Research Institute Helsinki Finland

4. Department of Physics and Astronomy University of Bologna Bologna Italy

5. Institute of Neurological Sciences of Bologna Bologna Italy

6. Department of Laboratory Medicine Clinical Research Center Karolinska Institute Stockholm Sweden

7. Center of Excellence in Translational Cancer Biology University of Helsinki Biomedicum Helsinki Helsinki Finland

8. Department of Pediatrics Oregon Stem Cell Center Oregon Health and Science University Portland OR

9. Yecuris Corporation Tualatin OR

10. Center for Inborn Errors of Metabolism University College London London UK

11. Department of Experimental, Diagnostic, and Specialty Medicine, and “L. Galvani” Interdepartmental Research Center University of Bologna Bologna Italy

12. Department of Clinical Science Intervention and Technology Division of Surgery Karolinska Institute at Karolinska University Hospital Huddinge Stockholm Sweden

13. Department of Laboratory Medicine Division of Pathology Karolinska Institute Stockholm Sweden

14. Department of Medicine Metabolism Unit Karolinska Institute at Karolinska University Hospital Huddinge Stockholm Sweden

15. Patient Area Nephrology and Endocrinology, Inflammation and Infection Theme Karolinska University Hospital Stockholm Sweden

Funder

Karolinska Institutet

Academy of Finland

Publisher

Wiley

Subject

Hepatology

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