Recent Advances of DNA Origami Technology and Its Application in Nanomaterial Preparation

Author:

Jiang Wenjing12ORCID,Li Jingrou1,Lin Zi'an3,Guo Jing3,Ma Jiaxin1,Wang Zhen1,Zhang Meizhou13ORCID,Wu Yuzhou3ORCID

Affiliation:

1. School of Life Science and Technology Wuhan Polytechnic University Wuhan 430023 China

2. School of Political Science & Public Administration Wuhan University Wuhan 430072 China

3. Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica Hubei Engineering Research Center for Biomaterials and Medical Protective Materials School of Chemistry and Chemical Engineering Huazhong University of Science and Technology Wuhan 430074 China

Abstract

In recent years, the unrivalled self‐assembly properties of DNA molecules have driven the rapid development of a new class of DNA self‐assembly technology—DNA origami technology. Over the past decade, this technology has enabled the construction of DNA nanostructures with different shapes, such as 2D and 3D structures. Meanwhile, the application of DNA origami are also developed rapidly. DNA origami structures are widely used in nanomaterial preparation and drug delivery due to their characteristics of accurate addressability, excellent programmability, and good biocompatibility, especially in the field of nanomaterial preparation. Such structures provide a new platform to construct nanomaterials with high precision. Herein, the development of DNA origami technology is introduced, and the research progress of 2D and 3D DNA origami in the past two decades is systematically summarized. Then, the application of DNA origami template in nanomaterial preparation is emphasized. Finally, the main challenges and opportunities for nanomaterials fabrication based on DNA origami technology are illustrated.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Wiley

Subject

General Earth and Planetary Sciences,General Environmental Science

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