Complex formation of anti‐VEGF‐C with VEGF‐C released during blood coagulation resulted in an artifact in its serum pharmacokinetics

Author:

Bumbaca Yadav Daniela1,Reyes Arthur E.1,Gupta Priyanka1,Vernes Jean‐Michel2,Meng Y. Gloria2,Schweiger Michelle G.3,Stainton Shannon L.3,Fuh Germaine4,Fielder Paul J.1,Kamath Amrita V.1,Shen Ben‐Quan1ORCID

Affiliation:

1. Preclinical and Translational Pharmacokinetics and Pharmacodynamics Department Genentech, Inc. South San Francisco CA USA

2. Biochemical and Cellular Pharmacology Department Genentech, Inc. South San Francisco CA USA

3. Safety Assessment Department Genentech, Inc. South San Francisco CA USA

4. Antibody Engineering Department Genentech, Inc. South San Francisco CA USA

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,Neurology

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