Surface mineralization with controlled polymerization of dopamine

Abstract

AbstractPolydopamine (PDA) has been utilized as a scaffolding for various biomedical applications since its discovery. This versatility arises from the unique property of PDA to coat virtually any surface and its high biocompatibility. In this study, PDA has been used to synthesize calcium phosphate in simulated body fluid on surfaces that normally could not form these mineral layers. PDA has the potential to reduce calcium phosphate. Due to its natural hydrophilicity and the high density of charged surface groups. Adjusting the reaction conditions has been shown to alter the properties of the PDA coatings and in turn the applications. In this study, we will observe how controlling the reaction conditions to adjust properties of PDA can alter the mineral layer formed on the polymer surface. By maximizing the surface area of the polymer, the number of polar groups on the surface available to bind the mineralization. We will illustrate both the degree of mineralization on the surface as well as the chemical content of the minerals. We will illustrate that the ability of PDA to form calcium phosphate can be enhanced to allow for better biocompatibility for biomedical implants.