Concise Review: Is Cardiac Cell Therapy Dead? Embarrassing Trial Outcomes and New Directions for the Future

Author:

Tang Jun-Nan123,Cores Jhon23,Huang Ke12,Cui Xiao-Lin4,Luo Lan5,Zhang Jin-Ying3,Li Tao-Sheng5,Qian Li6,Cheng Ke1237

Affiliation:

1. a Department of Cardiology The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People's Republic of China

2. b Department of Molecular Biomedical Sciences and Comparative Medicine Institute North Carolina State University, Raleigh, North Carolina, USA

3. c Joint Department of Biomedical Engineering University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina, USA

4. d Department of Orthopaedic Surgery University of Otago, Christchurch, New Zealand

5. e Department of Stem Cell Biology Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan

6. f Department of Pathology and Laboratory Medicine University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

7. g Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

Abstract

Abstract Stem cell therapy is a promising strategy for tissue regeneration. The therapeutic benefits of cell therapy are mediated by both direct and indirect mechanisms. However, the application of stem cell therapy in the clinic is hampered by several limitations. This concise review provides a brief introduction into stem cell therapies for ischemic heart disease. It summarizes cell-based and cell-free paradigms, their limitations, and the benefits of using them to target disease.

Publisher

Oxford University Press (OUP)

Subject

Cell Biology,Developmental Biology,General Medicine

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